Successful GDMT Optimization with Story Health

New Story Health data shows successful GDMT optimization in 90 days.

Cupertino, CA (Oct.10, 2022) - 

Story Health announced positive clinical results from patients with significant heart failure with reduced ejection fraction (HFrEF) showing significant guideline-directed medical therapy (GDMT) improvement in partnership with ChristianaCare.

At the 2022 Heart Failure Society of America’s (HFSA’s) Annual Scientific Meeting, Dr. Sourin Banerji, lead author and Medical Director of Advanced Heart Failure at ChristianaCare Health System, presented the results of 90 patients with advanced heart failure (American College of Cardiology and American Heart Association structural classification of Stage C and higher).

These patients were enrolled with Story Health, a digital hybrid platform that is technology-enabled and human-powered, to identify and orchestrate care plans. As part of Story Health’s platform, patients have dedicated health coaches that work in unison with that patient’s clinician to ensure that the care plan is followed and treatment goals are achieved. These health coaches serve as an extension of the clinician to identify and resolve challenges such as medication adherence, lab work coordination, lab work coordination, transportation arrangement, and even prescription assistance, that cause these disruptions in a patient’s care journey, negatively impacting patients.

After 90-days with Story Health, patients experienced significant improvements in achieving optimal dosing, defined as equal to or greater than 50% target dosing, which the ACC/AHA/HFSA guidelines recommends reaching for all patients with Heart Failure and Reduced Ejection Fraction (HFrEF) unless contraindicated. 

Specific highlights from the abstract include: 

  • 6x increase in the percentage of patients on all four pillars of GDMT medications after 90-days (68%) compared to baseline (11%)
  • 4x increase in the percentage of patients on target dose angiotensin converting enzyme inhibitor (ACEI), angiotensin receptor blocker (ARB) or angiotensin receptor-neprilysin inhibitor (ARNI) after 90-days (63%) compared to baseline (16%)
  • 2x increase in the percentage of patients on target doses of Beta-blockers, mineralocorticoid receptor antagonists (MRAs), and sodium glucose cotransporter-2 inhibitors (SGLT-2i) after 90-days (63%, 58%, 73%) compared to baseline (36%, 29%, 30%)

“Using Story Health, we have optimized our patients GDMT regimen to greater than 50% of target dosing in a short period of time compared favorably to national registries. These patients averaged an ejection fraction (EF) of 22% with American College of Cardiology (ACC) Stage C classification, and it’s really been transformational for many patients. We see every day how much better our patients are doing," said Dr. Sourin Banerji. “The platform is a synergy of technology, health coach support, and physician care and addresses gaps that impact patients between clinical visits. This has accelerated optimization of patient care and is a true working model for future healthcare delivery.”

ChristianaCare’s experiences are applicable to the over 6 million Americans that have heart failure that are struggling to manage and live with heart failure once they leave the specialist’s office. 

Dr. Adam DeVore, Associate Professor of Medicine from Duke University states, “The team at Christiana Care partnered with Story Health to try to improve medical therapy for patients with heart failure with reduced ejection fraction. Low use and dose of medical therapy for heart failure is a problem we see at our own Institution as well as in registries across the country. They used home-based titration plans paired with remote monitoring and health coaches and were able to significantly increase medication use and dosing from baseline. I am excited about these types of programs and look forward to learning more about their impact through randomized clinical trials.”

The complete poster publication of “Impacting Guideline Directed Medical Therapy Optimization With Story Health” can be viewed online.